At present, most BC patients with BM receive palliative treatment. More importantly, bone metastasis (BM) accounts for 50% of all distant metastases in these patient. It has been reported that the incidence of metastases in BC patients ranges from 20 to 30%. Recently, with the advancement of early diagnosis and comprehensive treatment, the mortality rate of BC has gradually decreased, and distant metastasis has become the main cause of death for these patients. Globally, there were approximately 2.1 million newly diagnosed female BC cases in 2018. This will help clinicians develop more rational and effective treatment strategies.īreast cancer (BC) is the most common malignancy and the leading cause of death among all female cancer patients. These nomograms are expected to be a precise and personalized tool for predicting the risk and prognosis for BM in patients with IDC. Through calibration, receiver operating characteristic curve and decision curve analyses, we found that the nomogram for predicting the prognosis of IDC patients with BM displayed great performance both internally and externally. The independent prognostic factors were brain metastases, race, grade, surgery, chemotherapy, age, liver metastases, breast cancer subtype, insurance status, and marital status. The risk factors for BM in patients with IDC included sex, primary site, grade, T stage, N stage, liver metastasis, race, brain metastasis, breast cancer subtype, lung metastasis, insurance status, and marital status. This study included 141,959 patients diagnosed with IDC in the SEER database, of whom 2383 cases were IDC patients with BM. The results were validated using bootstrap resampling and retrospective research on 113 IDC patients with BM from 2015 to 2018 at the Affiliated Hospital of Chengde Medical University. We then constructed nomograms to predict the risk and prognosis of BM for patients with IDC. Univariate and multivariate Cox proportional hazards regression analysis were used to explore the prognostic factors of BM in patients with IDC. ![]() Multivariate logistic regression analysis was used to identify risk factors for BM in patients with IDC. IDC patients with newly diagnosed BM from 2010 to 2016 in the Surveillance, Epidemiology and End Results (SEER) database were reviewed. However, there are no studies on diagnostic and prognostic nomograms for BM in newly diagnosed IDC patients. Some nomograms have been developed to predict bone metastasis (BM) in patients with breast cancer. Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients the most common pathological type of BC is infiltrating duct carcinoma (IDC).
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